2026
Prallet S, Maier N, Li A, Afting C, Huang HE,
Hu J,
Toprak E, Keya DP, Colasanti O, León-Janampa N, Marlet J, Beisel C, Mogler C, Puchas P, Behrendt P, Boettler T, Steinmann E, Saha S, Laketa V, Lohmann V, Wittbrodt J, Hermann C, Dill MT,
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Hu J, Liu T, Klöhn M,
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Dao Thi VL. (2026). Nucleotide analogue bemnifosbuvir inhibits hepatitis E virus replication in preclinical models.
Gut gutjnl-2025-336714
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2025
Mehnert AK, Stegmaier S, Ramirez Alvarez C,
Toprak E, Magalhães VG, Siebenkotten C,
Hu J, Costa AL, Kirrmaier D, Knop M, Wu X, Tubiana T, Herrmann C, Binder M,
Dao Thi VL. (2025). The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistent replication in cell culture.
PLoS Pathog. 21(9):e1013516
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Fu R,
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Chi H, Burbano de Lara S, Helm B, Klöhn M,
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Freistaedter A, Boettler T, Binder M, Klingmüller U, Steinmann E, Lozach PY, Tubiana T, Lemon SM,
Dao Thi VL. (2025). Integrin beta 1 facilitates non-enveloped hepatitis E virus cell entry through the recycling endosome.
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Ssebyatika G, Dinkelborg K, Ströh LJ, Hinte F, Corneillie L, Hueffner L, Guzman EM, Nankya PL, Plückebaum N, Fehlau L, Garn J, Meyer N,
Prallet S,
Mehnert AK, Kraft ARM, Verhoye L, Jacobsen C, Steinmann E, Wedemeyer H, Viejo-Borbolla A,
Dao Thi VL, Pietschmann T, Lütgehetmann M, Meuleman P, Dandri M, Krey T, Behrendt P. (2025). Broadly neutralizing antibodies isolated from HEV convalescents confer protective effects in human liver-chimeric mice.
Nat Commun. 16(1):1995
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Dao Thi VL (2024). An hepatitis B and D virus infection model using human pluripotent stem cell-derived hepatocytes.
EMBO Rep. 25(10):4311–4336
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Klöhn M, Burkard T, Janzen J, Haase JA, Gömer A,
Fu R, Ssebyatika G, Nocke MK, Brown RJP, Krey T,
Dao Thi VL, Kinast V, Brüggemann Y, Todt D, Steinmann E. (2024). Targeting cellular cathepsins inhibits hepatitis E virus entry.
Hepatology 80(5):1239–1251
PubMed2023
Csernalabics B, Marinescu MS, Maurer L, Kelsch L, Werner J, Baumann K, Zoldan K, Panning M, Reuken P, Bruns T, Bengsch B, Neumann-Haefelin C, Hofmann M, Thimme R,
Dao Thi VL, Boettler T. (2023). Efficient formation and maintenance of humoral and CD4 T-cell immunity targeting the viral capsid in acute-resolving hepatitis E infection.
J Hepatol. 80(4):564–575
PubMedSchrader JA, Burkard TL, Brüggemann Y, Goemer A, Meister TL,
Fu R,
Mehnert AK,
Dao Thi VL, Behrendt P, Durantel D, Broering R, Vondran FWR, Todt D, Kinast V, Steinmann E. (2023). EGF receptor modulates HEV entry in human hepatocytes.
Hepatology. 77(6):2104–2117
PubMed2022
Maurer L, El Andari J, Rapti K,
Spreyer L, Steinmann E, Grimm D,
Dao Thi VL (2022). Induction of Hepatitis E virus anti-ORF3 antibodies from systemic administration of a muscle-specific adeno-associated virus (AAV) vector.
Viruses 14(2), 266
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Zhang C,
Freistaedter A, Schmelas C, Gunkel M,
Dao Thi VL, Grimm D (2021). An RNA interference/adeno-associated virus vector-based combinatorial gene therapy approach against Hepatitis E virus.
Hepatol Commun. 6(4):878–888
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Mehnert A-K,
Dao Thi VL (2021). Chapter 7, iPSCs for modeling hepatotropic pathogen infections.
Advances in Stem Cell Biology, Academic Press, Volume 8, p. 149–213.
Science Direct
Herbst K, Meurer M, Kirrmaier D, Anders S, Knop M,
Dao Thi VL (2021). Colorimetric RT-LAMP and LAMP-sequencing for Detecting SARS-CoV-2 RNA in Clinical Samples.
Bio Protoc. 11(6):e3964
Bio Protoc2020
Dao Thi VL, Herbst K, Boerner K, Meurer M, Kremer LPM, Kirrmaier D,
Freistaedter A, Papagiannidis D, Galmozzi C, Stanifer ML, Boulant S, Klein S, Chlanda P, Khalid D, Miranda IB, Schnitzler P, Kräusslich H-G, Knop M, Anders S (2020). A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples.
Science Translational Medicine. 12:eabc7075
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Klein S, Müller TG, Khalid D, Sonntag-Buck V, Heuser A-M, Glass B, Meurer M, Morales I, Schillak A,
Freistaedter A, Ambiel I, Winter SL, Zimmermann L, Naumoska T, Bubeck F, Kirrmaier D, Ullrich S, Barreto Miranda I, Anders S, Grimm D, Schnitzler P, Knop M, Kräusslich H-G,
Dao Thi VL, Börner K, Chlanda P (2020). SARS-CoV-2 RNA Extraction Using Magnetic Beads for Rapid Large-Scale Testing by RT-qPCR and RT-LAMP.
Viruses. 12:863
VirusesDao Thi VL, Wu X, Belote RL, Andreo U, Takacs CN, Fernandez JP, Vale-Silva LA, Prallet S,
Decker CC,
Fu RM, Qu B, Uryu K, Molina H, Saeed M, Steinmann E, Urban S, Singaraja RR, Schneider WM, Simon SM, Rice CM (2020). Stem cell-derived polarized hepatocytes.
Nature Communications. 11:1677
Nat Comm
2019
Fu RM,
Decker CC,
Dao Thi VL (2019). Cell Culture Models for Hepatitis E Virus.
Viruses. 11:608
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Wang J, Qu B, Zhang F,
Zhang C, Deng W,
Dao Thi VL, Xia Y (2019). Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research.
Stem Cells International. 2019:9605252
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Dao Thi VL, Wu X, Rice CM (2018). Stem cell-derived culture models of hepatitis E virus infection.
Cold Spring Harbor Perspectives in Medicine. a031799
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Wu X*,
Dao Thi VL*, Liu P, Takacs CN, Xiang K, Andrus L, Gouttenoire J, Moradpour D, Rice CM (2018). Pan-Genotype Hepatitis E Virus Replication in Stem Cell-Derived Hepatocellular Systems.
Gastroenterology. 154:663–674
PubMedTodt D, Moeller N, Praditya D, Kinast V, Friesland M, Engelmann M, Verhoye L, Sayed IM, Behrendt P,
Dao Thi VL et al. (2018). The natural compound silvestrol inhibits hepatitis E virus (HEV) replication
in vitro and
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Antiviral Research. 157:151–158
PubMedKnegendorf L, Drave SA,
Dao Thi VL, Debing Y, Brown RJP, Vondran FWR, Resner K, Friesland M, Khera T, Engelmann M
et al. (2018). Hepatitis E virus replication and interferon responses in human placental cells.
Hepatology Communications. 2:173–187
PubMedWu X,
Dao Thi VL, Huang Y, Billerbeck E, Saha D, Hoffmann H-H, Wang Y, Vale Silva LA, Sarbanes S, Sun T
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Cell. 172:423–438
PubMedChung H, Calis JJA, Wu X, Sun T, Yu Y, Sarbanes SL,
Dao Thi VL, Shilvock AR, Hoffmann HH, Rosenberg BR
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ADAR1 prevents endogenous RNA from triggering translational shutdown.
Cell. 172:811–824
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Takacs CN, Andreo U,
Dao Thi VL, Wu X, Gleason CE, Itano MS, Spitz-Becker GS, Belote RL, Hedin BR, Scull MA
et al. (2017). Differential regulation of lipoprotein and hepatitis C virus secretion by Rab1b.
Cell Reports. 21:431–441
PubMedDao Thi VL, Debing Y, Wu X, Rice CM, Neyts J, Moradpour D, Gouttenoire J (2016). Sofosbuvir inhibits hepatitis E virus replication
in vitro and results in an additive effect when combined with ribavirin.
Gastroenterology. 150:82–85
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Hiroz P, Gouttenoire J,
Dao Thi VL, Doerig C, Moradpour D, Sahli R, Telenti A (2013). Mise à jour sur l’hépatite E.
Revue Médicale Suisse. 9:1594–1598
JournalMolina-Jimenez F, Benedicto I,
Dao Thi VL, Gondar V, Lavillette D, Marin JJ, Briz O, Moreno-Otero R, Aldabe R, Baumert TF, Cosset FL, Lopez-Cabrera M, Majano PL (2012). Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle.
Virology. 425:31–39
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